LA Mayor Karen Bass issued an overnight curfew for about 1 square mile in downtown LA, which has been the site of clashes between police and protesters over the last six days.

The National Guard has at times detained protesters in its deployment to Los Angeles, an official said Wednesday, as demonstrations against Immigration and Customs enforcement raids spread to other major cities.

The curfew went into effect in part of downtown Los Angeles amid ongoing protests over the Trump administration’s immigration crackdown.