The role of syncytia during viral infections - PubMed
WEBSep 21, 2021 · Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract. RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together.
High-throughput screening of genetic and cellular drivers of syncytium …
WEBNov 23, 2023 · SARS-CoV-2 induces syncytium formation when the spike protein on the surface of an infected cell interacts with receptors on neighbouring cells. Syncytia potentially contribute to pathology by ...
The role of syncytia during viral infections - ScienceDirect
WEBSep 21, 2021 · Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract. RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together.
Syncytia formation during SARS-CoV-2 lung infection: a ... - Nature
WEBMay 12, 2021 · Syncytia can also be induced by certain types of infections by viruses, such as human immunodeficiency virus, respiratory syncytial virus, and herpes simplex virus [9]. It could be envisioned...
Syncytia formation by SARS‐CoV‐2‐infected cells - PMC
WEBDec 12, 2020 · Expression of S without any other viral proteins triggers syncytia formation. Interferon‐induced transmembrane proteins (IFITMs), a family of restriction factors that block the entry of many viruses, inhibit S‐mediated fusion, with IFITM1 being more active than IFITM2 and IFITM3.
SARS-CoV-2 spike protein dictates syncytium-mediated ... - Nature
WEBApr 20, 2021 · In order to establish a causal link between SARS-CoV-2 infection and syncytium formation, SARS-CoV-2 viruses were employed to infect Vero-E6 cells, a cell line used for routine virus culture.
Syncytia formation by SARS-CoV-2-infected cells - PubMed
WEBDec 1, 2020 · Expression of S without any other viral proteins triggers syncytia formation. Interferon-induced transmembrane proteins (IFITMs), a family of restriction factors that block the entry of many viruses, inhibit S-mediated fusion, with IFITM1 being more active than IFITM2 and IFITM3.
Drivers and Distribution of Henipavirus-Induced Syncytia: What Do …
WEBSep 2, 2021 · We highlight the observed patterns and their concordance or discordance between in vitro and in vivo studies, discuss the fundamental and practical implications, and identify future directions for the study of virus-induced syncytium formation.
Virus-Induced Cell Fusion and Syncytia Formation
WEBNov 24, 2023 · Many viruses can induce cell-cell fusion and syncytia formation. For most enveloped viruses, such as HIV-1 and SARS-COV-2, this cell-cell fusion process is mediated by the interactions between viral fusion proteins and their cognate receptors.
The role of syncytia during viral infections - ScienceDirect
WEBSep 21, 2021 · Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract. RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together.