Spike mutation D614G alters SARS-CoV-2 fitness - Nature
WEBOct 26, 2020 · Here we engineered the spike D614G substitution in the USA-WA1/2020 SARS-CoV-2 strain, and found that it enhances viral replication in human lung epithelial cells and primary human airway tissues...
The D614G mutations in the SARS-CoV-2 spike protein: …
WEBJan 1, 2021 · A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics …
The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding ...
WEBSARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission.
Spike D614G — A Candidate Vaccine Antigen Against Covid-19
WEBJun 16, 2021 · In late February 2020, a point mutation in the SARS-CoV-2 spike protein, the D614G variant, was identified. The presence of this mutation predicts the substitution of the amino acid...
SARS-CoV-2 spike-protein D614G mutation increases virion spike …
WEBNov 26, 2020 · SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (SG614) with the original (SD614).
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G …
WEBAug 8, 2020 · A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal.
The D614G mutation redirects SARS-CoV-2 spike to lysosomes …
WEBDec 23, 2022 · We show that the Spike D614G mutation enhances Spike trafficking to lysosomes, drives Spike-mediated reprogramming of lysosomes, and reduces cell surface Spike expression by ~3-fold. D614G is not a human-specific adaptation.
SARS-CoV-2 D614G spike mutation increases entry efficiency with ...
WEBFeb 8, 2021 · SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher...
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to ...
WEBJan 13, 2021 · The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation early in the pandemic that confers greater infectivity and is now the globally dominant form.
Spike mutation D614G alters SARS-CoV-2 fitness - PubMed
WEBHere we engineered the spike D614G substitution in the USA-WA1/2020 SARS-CoV-2 strain, and found that it enhances viral replication in human lung epithelial cells and primary human airway tissues by increasing the infectivity and stability of virions.